The Science of Personalization

Your biology is not average. Neither is the research behind it. Explore expert insights, educational content and the science that powers Trifecta Health across genomics, longevity, supplementation and performance.

Research and Resources

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Our Ingredients

Most supplement companies start with a formula and put your name on it. Trifecta Health starts with your DNA and builds from there. That means every ingredient is chosen because a specific genetic pathway in your biology called for it. No guesswork. No averages. No filler.

Every compound is pharmaceutical-grade, sourced at therapeutic doses and compounded individually in a licensed facility without fillers, flow agents or unnecessary additives. Some of what’s in your formula you won’t find anywhere on a retail shelf, because these are compounds that are expensive to source, require precise dosing and only make sense when your DNA tells us your body actually needs them.

An AM blend and a PM blend, timed to how your body actually uses each compound. No two formulas are alike because no two people are alike. That’s not a marketing line. It’s how compounding works.

Foundational Compounds

Every Trifecta formula is built on a core of foundational compounds:
essential nutrients your body requires to function at its best, precisely dosed.

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Methylation & Nutrient Processing 

TMG (Betaine)

500mg

Derived from beets, this methyl donor provides a backup methylation pathway that works even when your primary MTHFR system is compromised. Think of it as the alternate route your GPS offers when the main highway is congested. 

Methylation & Nutrient Processing 

Phosphatidylcholine

300mg

The building block of every cell membrane in your body. Your DNA may reveal that you produce less of this critical phospholipid than you need — which can affect brain function, liver health, and cellular communication throughout your entire system. 

Methylation & Nutrient Processing 

SAMe

200mg

Your body’s universal methyl donor — participating in over 200 methylation reactions that affect your DNA expression, neurotransmitters, joint health, and liver function. When your methylation cycle slows down due to genetic variants, SAMe production drops — and supplementation helps bridge the gap. 

Physical Fitness & Energy 

ALCAR

500mg

Acetyl-L-Carnitine — the delivery truck that carries fatty acids into your mitochondria to be burned for energy. The acetyl group also crosses into your brain to support memory and focus. Selected when your DNA suggests your muscles are wired for endurance rather than power. 

Physical Fitness & Energy 

L-Citrulline

1000mg

Found naturally in watermelon, this amino acid converts to arginine in your kidneys to produce nitric oxide — the molecule that relaxes blood vessels and improves blood flow. It actually works better than taking arginine directly. Selected when your DNA shows your nitric oxide production pathway needs a boost. 

Physical Fitness & Energy 

PQQ

20mg

Pyrroloquinoline quinone is one of the most exciting nutrients in modern science. PQQ literally commands your cells to build new mitochondria — your cellular power plants. A 12-week clinical trial showed measurable cognitive improvement. It’s 100–1000 times more efficient at recycling antioxidants than vitamin C. 

Physical Fitness & Energy 

Panax Ginseng 

300mg

The king of adaptogens, used for thousands of years in Korean and Chinese medicine. Modern clinical trials in 90 subjects with mild cognitive impairment confirmed that it sharpens mental clarity while helping your stress response system stay balanced. Among the top 10 best-selling herbal supplements worldwide. 

Brain Health & Neurochemistry 

L-Theanine 

200mg

The calm-focus amino acid from green tea. Within 30 minutes, it shifts your brain into alpha-wave mode — the same relaxed-but-alert state you experience during meditation. It takes the edge off without making you drowsy. Especially valuable if your DNA indicates heightened stress sensitivity. 

No fillers. No overlap. No bottles you’re not sure about.

Just two blends. AM and PM.
Because what your body needs in the morning is not what it needs at night.
Compounded from scratch. Delivered to your door.
Your entire supplement routine, replaced with one that actually works.

FAQs

Is Trifecta Health a supplement company? 

No. Trifecta Health is a precision health company that produces supplements. The supplement is the output. The work is genomic sequencing, expert interpretation, personalized planning and ongoing coaching. The formula your body receives is the result of that entire system working together. Without the DNA analysis, the consultation and the custom compounding, it’s just another bottle on a shelf. 

How is Trifecta Health different from a concierge longevity clinic? 

Concierge longevity clinics offer a version of what Trifecta Health offers, but at $50,000 to $150,000 a year, accessible only to a small number of people and typically requiring in-person visits, blood draws and ongoing appointments. Trifecta Health was built to make the same level of genomic precision and personalized supplementation available to anyone who is serious about their health, at a fraction of the cost, starting from home.

What is genomic sequencing and how is it different from consumer DNA tests like 23andMe? 

Consumer DNA tests look at a limited set of genetic markers, typically focused on ancestry and a narrow range of health traits. Trifecta Health uses comprehensive genomic sequencing that examines a much fuller picture of your biology, including the specific genetic pathways that govern how your body processes nutrients, responds to exercise, manages inflammation, metabolizes hormones and ages at the cellular level. It’s the difference between a partial map and the complete blueprint.

Do I need to visit a clinic or doctor to the DNA test?

No. Everything begins at home. Your DNA collection kit arrives by mail and uses a simple saliva swab. No blood draw, no clinic visit, no appointment required to get started. Your 1:1 consultation with a Trifecta Health Coach happens virtually.

What does my Trifecta Health membership package include? 

Included in the Trifecta Health (adult) membership plan:

  • Comprehensive genomic testing and results report.
  • Personalized supplement list, based on your DNA.
  • Expert 1:1 consultation with a Trifecta Health Coach (one hour session).
  • Access to the Trifecta Health membership portal.
  • Comprehensive genomic testing and results report.
  • Your first month's supply of custom-compounded supplements, based on your chosen tier (Precision or Prestige) is included, along with enrollment in a monthly subscription. First month of 24/7 access to TRIA, your personal AI genomics assistant trained on your DNA. Members who have active custom-compounded supplement subscriptions will maintain access to TRIA.  

 Included in the Trifecta Health (child) membership plan:  

  • Comprehensive genomic testing and results report.
  • Personalized supplement list, based on your DNA.
  • Expert 1:1 consultation with a Trifecta Health Coach with the consenting parent/guardian of the child (one hour session).
  • Access to the Trifecta Health membership portal for the consenting parent/guardian of the child.
  • Access to TRIA for a period of 12 months.
How does Trifecta Health create my custom-compounded supplements formula? 

Your genomic report identifies which health pillars your genetics have triggered. Each pillar activates a specific set of ingredients selected because a genetic pathway in your DNA calls for them. The doses are calibrated to your profile and every ingredient works alongside the others as a coordinated system. Those ingredients are split into two formulas: an AM blend and a PM blend, timed to how your body actually uses them. Your formula is compounded individually in a licensed facility. No off-the-shelf ingredients. No pre-made blends. No two formulas are alike because no two genetic profiles are alike.

What is the difference between Precision and Prestige? 

Both supplement plans are built from your DNA and include comprehensive genomic sequencing.. Precision focuses on the core 8 health pillars: diet and heart health, sensitivities, specific nutrient needs, brain health, hormone health, detoxification, physical fitness and metabolic health. Prestige adds a focus on 5 advanced optimization pillars: longevity and anti-aging, beauty and skin health, gut and microbiome support, sexual health and vitality and bone and joint health. Prestige also includes two reformulation consultations versus one for Precision. For those who want everything working at the highest level, Prestige is the optimal system.

How does my supplement subscription work?

Your first month supply of custom-compounded supplements, based on your chosen tier (Precision or Prestige) is included in your Trifecta Health membership package, along with enrollment in a monthly subscription.

Beginning 30 days after your initial order, your credit card will be charged every 30 or 90 days – depending on your selected subscription cadence – for your recurring supplement order.  

How are the supplements delivered and how often? 

Your custom-compounded formula arrives at your door in AM and PM blends every 30 or 90 days depending on your subscription. A 90-day supply saves 15%. Your formula can be updated over time as your health evolves.  

How is my supplements formula updated over time? 

Your formula is a living document. As you age, as your health evolves and as your results come in, your Trifecta Health team can adjust your formula to reflect what your body needs at each stage. This is fundamentally different from any subscription supplement service where the formula never changes.

The Prestige plan includes up to two formula reformulations a year versus one for Precision.  

If required, a reformulation of your custom-compounded supplements can be requested through the membership portal contact form or by emailing concierge@trifecta.health at least 10 business days before your next scheduled subscription payment date. Also, the reformation intake form must be completed at least seven business days before your next scheduled subscription payment date.

How do I pause or cancel my supplements subscription? 

You may cancel your subscription at any time. To do so, please submit a written cancellation request through the membership portal contact form or by emailing concierge@trifecta.health at least five business days before your next scheduled payment date.


What makes the ingredients in my Trifecta Health formula different from what I can buy at a health food store?

Every ingredient in your formula is selected because your DNA called for it, dosed at a clinically meaningful level and compounded without fillers, flow agents or additives. Off-the-shelf supplements are formulated for the average person at the average dose. Your formula doesn’t start from an average. It starts from your genome. The ingredients are also professionally sourced at therapeutic grades that most retail products don’t reach.

What makes the ingredients in my Trifecta Health formula different from what I can buy at a health food store? 

Every ingredient in your formula is selected because your DNA called for it, dosed at a clinically meaningful level and compounded without fillers, flow agents or additives. Off-the-shelf supplements are formulated for the average person at the average dose. Your formula doesn’t start from an average. It starts from your genome. The ingredients are also professionally sourced at therapeutic grades that most retail products don’t reach.

Why does my formula split into AM and PM blends? 

Because what your body needs in the morning is not what it needs at night. Some compounds work best taken with food and support energy, focus and metabolism during active hours. Others absorb better on an empty stomach and support recovery, detoxification and cellular repair while you sleep. Your AM and PM blends are timed to how your body actually uses each compound. This isn’t a convenience feature. It’s how the formula works.

I already eat well and exercise. Do I still need this? 

Possibly more than most. The people who invest most in their health are often the ones most frustrated by the gap between their effort and their results. That gap is frequently genetic. You may be doing everything right for the average person and still missing what your specific biology actually needs. Your DNA tells us where those gaps are. Your formula fills them.

What is TRIA and how is it different from other AI health tools? 

TRIA  is not a chatbot. It is not ChatGPT. It is not a search engine that gives everyone the same answer. TRIA is an AI health coach trained specifically on your personal DNA. It knows your biology, your weak points and what’s viable for your body. Every answer it gives is built around your actual genome, not a generalized database. That’s what makes the guidance Trifecta Health provides fundamentally more precise and more useful than anything else available.

Is this right for my family? 

Yes. The Trifecta Health Family plan was built specifically for households. Even children from the same parents are biologically unique and distinct. Their nutritional needs are not the same and the average children’s vitamin accounts for none of that. The Family plan includes full genomic sequencing for two adults and two children, 1:1 consultations and custom-compounded supplements for both adults, personalized health insights for each child and 24/7 TRIA coaching for the entire family.

What are foundational versus premium compounds? 

Every Trifecta Health formula is built on a core of foundational compounds: the nutrients your body absolutely requires to function at its best, precisely dosed and free of fillers. Premium compounds are optional additions available in the Prestige program, sourced at the frontier of longevity and performance science. Which ones appear in your formula depends entirely on which of your health pillars are triggered by your genomic results.

Will you sell my genetic data with third parties? 

No.  Your genetic data is never sold  to third parties. Check out our Privacy Policy [hyperlink] to review the full Disclosure of Personal Data.  

Your Formula Is Waiting.

It doesn’t exist yet.
It won’t until your DNA tells us exactly what to build.

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